Value of Tc99m (V) Dmsa Compared to Tc99m Mibi in Evaluation of Bone and Bone Marrow Lesions in Patients with Multiple Myeloma.

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Value of tc99m (V) dmsa compared to tc99m Mibi in Evaluation of Bone and Bone Marrow Lesions in Patients with Multiple Myeloma

Bone scintigraphy has some limitations in detecting bone lesions at the time of diagnosis since Tc99m MDP scintigraphy does not trace lesions lacking osteoblastic activity3. Tc99m Sestamibi (MIBI) has been proposed as a potential tracer in patients with multiple myeloma, as its increased uptake in the bone marrow has been reported as an indicator of myeloma activity4. It has been suggested to b...

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In vitro Effect of Pomalidomide on Bone Marrow Mononuclear Cells from Multiple Myeloma Patients

Background: Many features of anticancer drugs, including cytotoxicity and/or cytokine induction, are studied using cell lines orhuman blood leukocytes. However, in a disease such as multiple myeloma, most cancerous cells are resided within bone marrowmononuclear cells. In the present study, we investigated the effect of pomalidomide on apoptosis and IL-2 production of bonemarrow mononuclear cel...

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Accumulation of Tc99m-DMSA-3 in the spleen in a case of multiple myeloma with associated amyloidosis.

We describe a case of a 58-year-old male with longstanding hypertension and Type 2 diabetes mellitus who developed sudden onset renal impairment. The first clue to the possible presence of amyloidosis in this case was provided by the radionuclide renal cortical scan performed with trivalent dimercapto succinic acid (Tc99m-DMSA-3), which revealed intense tracer uptake in the spleen suggesting am...

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The Role of Bone Marrow Aspiration and Bone Marrow Biopsy in Diagnosis of Bone Marrow Metastases

Background: Bone marrow is the site of many malignant disorders and it is one of the common places for solid tumors to metastasize. Examination of the bone marrow aspirate and biopsy is a routine procedure performed for assessment of various conditions such as cytopenias, hematologic neoplasms, nonmalignant disorders and metastatic neoplasms. Methods: The patients were referred to the Hema...

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ژورنال

عنوان ژورنال: Research in Oncology

سال: 2011

ISSN: 2357-0695

DOI: 10.21608/resoncol.2011.430